Because herbal medicines have fewer side effects and may treat a wide range of illnesses, they are becoming more and more popular. Nevertheless, due to their high first-pass metabolism and potential instability in acidic pH, they offer fewer therapeutic benefits. Herbal medications are incorporated into nanoparticles, which are made with phytoconstituents that are derived from plants, in order to overcome these restrictions. Hot and cold homogenization are methods for loading nanoparticles that entail heating the drug in a surfactant solution and then cooling it with cryogenic equipment. These techniques are frequently employed to create formulations of lipid-based nanoparticles.