While topical application causes a natural aggregation of solid nanoparticles in follicular openings that gives a medicine a “targeting effect,” nanotechnology has undoubtedly been investigated for the treatment of problems affecting hair follicles.

1.Hair Follicle Delivery: The hair follicle wall is an infundibulum, isthmus, and upper part of the hair follicle that is an invasion of the epidermis with a generally stable composition of cells.

Drugs can permeate skin cells or the stratum corneum’s extracellular matrix after being applied topically (the most superficial epidermal layer). Additionally, they can employ hair follicles as shunt routes.

The medication’s physicochemical properties (size, molecular weight, and oil–water partition coefficient) and the size of the nanoformulation it is integrated in affect how successfully the drug is delivered to hair follicles.

2.Nanostructured Lipid Carriers (NLCs):

Lipid-based nanoparticles known as nanostructured lipid carriers, or NLCs, have the potential to improve medication delivery. The potential of grape seed oil laden NLCs to stimulate hair growth has been investigated.

3. Evaluation Techniques: Researchers employ a variety of skin models and quantitative and qualitative analytic techniques to evaluate the hair follicle-targeted medication delivery offered by nanoparticles.

Study outcomes are greatly impacted by variables such as the kind of skin model used, the skin portions examined, the controls used, and the extraction techniques.

To summarise, NLCs provide an intriguing approach to augmenting the effectiveness of natural oils such as grape seed essential oil, while nanotechnology shows promise for targeted medication delivery to hair follicles.